T and B cells recognize splicing-derived neutrophil neoantigens in lupus

2026-10-29来源 Nature NewsEnglish

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11219-7

In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing neoantigen-driven autoimmune immunity.

原文：https://www.a8q9.cn/en/article/t-and-b-cells-recognize-splicing-derived-neutrophil-neoantigens-in-lupus-d0d7e9.html

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