MCT1-dependent mitochondrial lactate import sustains cardiac metabolism

2026-10-29来源 Nature NewsEnglish

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11182-3

In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and NADH, sustaining cardiac energetics and preventing stress-induced heart failure.

原文：https://www.a8q9.cn/en/article/mct1-dependent-mitochondrial-lactate-import-sustains-cardiac-metabolism-adae2f.html

MCT1-dependent mitochondrial lactate import sustains cardiac metabolism

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