Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activation

2026-10-07来源 Nature NewsEnglish

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11113-2

BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the formation of activation foci at the γ-globin genes.

原文：https://www.a8q9.cn/en/article/human-genetics-implicates-a-bach2-nrf2-axis-in-fetal-haemoglobin-activation-8db688.html

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