GRP75-dependent SIMPA mediates inter-organellar quality control

2026-10-22来源 Nature NewsEnglish

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-y

Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

原文：https://www.a8q9.cn/en/article/grp75-dependent-simpa-mediates-inter-organellar-quality-control-2e2fbc.html

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